Each month many women experience an ovulatory cycle that regulates fertility. Whereas research finds that this cycle influences women’s mating preferences, we propose that it might also change women’s political and religious views. Building on theory suggesting that political and religious orientation are linked to reproductive goals, we tested how fertility influenced women’s politics, religiosity, and voting in the 2012 U.S. presidential election. In two studies with large and diverse samples, ovulation had drastically different effects on single versus married women. Ovulation led single women to become more liberal, less religious, and more likely to vote for Barack Obama. In contrast, ovulation led married women to become more conservative, more religious, and more likely to vote for Mitt Romney. In addition, ovulatory- induced changes in political orientation mediated women’s voting behavior. Overall, the ovulatory cycle not only influences women’s politics, but appears to do so differently for single versus married women.