Every cell in our bodies runs on a 24-hour clock, tuned to the night-day, light-dark cycles that have ruled us since the dawn of humanity. The brain acts as timekeeper, keeping the cellular clock in sync with the outside world so that it can govern our appetites, sleep, moods, and much more.

But new research shows that the clock may be broken in the brains of people with depression—even at the level of the gene activity inside their brain cells.

It’s the first direct evidence of altered circadian rhythms in the brain of people with depression, and shows that they operate out of sync with the usual ingrained daily cycle. […]

In severely depressed patients, the circadian clock was so disrupted that a patient’s “day” pattern of gene activity could look like a “night” pattern—and vice versa.

{ Futurity | Continue reading | Thanks Tim }

The capacity to deceive others is a complex mental skill that requires the ability to suppress truthful information. The polygraph is widely used in countries such as the USA to detect deception. However, little is known about the effects of emotional processes (such as the fear of being found guilty despite being innocent) on the physiological responses that are used to detect lies. The aim of this study was to investigate the time course and neural correlates of untruthful behavior by analyzing electrocortical indexes in response to visually presented neutral and affective questions. […]

The ERP data [An event-related potential (ERP) is the measured brain response that is the direct result of a specific sensory, cognitive, or motor event] show the existence of a reliable neural marker of lying in the form of an increased amplitude of the N400 component (which likely indexes conscious control processing) in frontal and prefrontal regions of the left hemisphere between 300 and 400 ms post-stimulus. Importantly, this marker was observed to be independent of the affective value of the question.

{ PLoS | Continue reading }

photo { Adam Broomberg & Oliver Chanarin }

Insomnia, euphoria, anxiety and obsession; modern science shows us that these symptoms are just as likely to be found in someone who is deeply in love as someone who is having mental problems. Should these people be once again diagnosed as having “lovesickness”, as they would have been in the past? […]

Although lovesickness is not used as a medical diagnosis anymore, recent research in the fields of clinical psychology, psychiatry and neuroscience has more fully consolidated the pathological components of passionate love, showing that people in love are not so different from patients suffering bipolar disorder, obsessive-compulsive disorder and substance-related disorders.

{ United Academics | Continue reading }

Quantum Archaeology (QA) is the controversial science of resurrecting the dead including their memories. It assumes the universe is made of events and the laws that govern them, and seeks to make maps of brain/body states to the instant of death for everyone in history.

Anticipating process technologies due in 20 – 40 years, it involves construction of the Quantum Archaeology Grid to plot known events filling the gaps by cross-referencing heuristically within the laws of science. Specialist grids already exist waiting to be merged, including cosmic ones with trillions of moving evolution points. The result will be a mega-matrix good enough to describe and simulate the past. Quantum computers and super-recursive algorithms both in their infancy may allow vast calculation into the quantum world, and artificial intelligence has no upper limit to what it might do.

{ Transhumanity | Continue reading }

photo { Erwin Olaf }

Don’t mistake addiction for love. This is tricky because, neurochemically speaking, the two are very similar–studies have shown that when romantic partners who are intensely in love are exposed to photographs of their beloved, the brain regions that become activated are the same regions that are activated in cocaine addicts when they are craving cocaine. But even if love has some addiction-like qualities, healthy love is likely to involve other qualities as well, such as respect, trust, and commitment, qualities that keep a relationship strong even on those days when excitement and passion are not at the forefront. Addictive love, by contrast, tends to be more singularly focused on attaining those “highs,” whatever the cost. Partners whose behavior is unpredictable (e.g., they don’t call when they say they will), are, unfortunately, especially likely to keep you hooked, since their inconsistent affection keeps you on your toes and wanting more. If you are trying to break free from a relationship that feels more like an addiction than a loving bond,  one strategy is to reframe your thoughts and emotions about that person as if they are cold, clinical biological processes in order to gain a healthy distance from them. For example, after a week of not calling Mr. or Ms. Wrong, you feel a wave of longing in your chest and think, “But I really do love him/her… I should call him/her right now…” Instead, you could notice that sensation and tell yourself, “Interesting, there goes my caudate nucleus releasing dopamine and producing a sensation of longing. Okay, back to work.”

{ Psych Your Mind | Continue reading }

All seems to indicate that the next decade, the 20s, will be the magic decade of the brain, with amazing science but also amazing applications. With the development of nanoscale neural probes and high speed, two-way Brain-Computer interfaces (BCI), by the end of the next decade we may have our iPhones implanted in our brains and become a telepathic species. […]

Last month the New York Times revealed that the Obama Administration may soon seek billions of dollars from Congress for a Brain Activity Map (BAM) project. […] The project may be partly based on the paper “The Brain Activity Map Project and the Challenge of Functional Connectomics” (Neuron, June 2012) by six well-known neuroscientists. […]

A new paper “The Brain Activity Map” (Science, March 2013), written as an executive summary by the same six neuroscientists and five more, is more explicit: “The Brain Activity Map (BAM), could put neuroscientists in a position to understand how the brain produces perception, action, memories, thoughts, and consciousness… Within 5 years, it should be possible to monitor and/or to control tens of thousands of neurons, and by year 10 that number will increase at least 10-fold. By year 15, observing 1 million neurons with markedly reduced invasiveness should be possible. With 1 million neurons, scientists will be able to evaluate the function of the entire brain of the zebrafish or several areas from the cerebral cortex of the mouse. In parallel, we envision developing nanoscale neural probes that can locally acquire, process, and store accumulated data. Networks of “intelligent” nanosystems would be capable of providing specific responses to externally applied signals, or to their own readings of brain activity.”

{ IEET | Continue reading }

photo { Adam Broomberg & Oliver Chanarin }

How did we become neurochemical selves? How did we come to think about our sadness as a condition called “depression” caused by a chemical imbalance in the brain and amenable to treatment by drugs that would “rebalance” these chemicals? How did we come to experience our worries at home and at work as “generalized anxiety disorder” also caused by a chemical imbalance which can be corrected by drugs?

{ Nikolas Rose | PDF | More: The rise of everyday neuroscience }

In Proust’s novel À la Recherche du Temps Perdu the narrator, Marcel, is overwhelmed by an unexpectedly vivid memory triggered by dipping a madeleine into a cup of tea. Such experiences are now being classified as involuntary autobiographical memories (IAMs), coming to mind without any deliberate attempt at retrieval. Ebbinghaus (1885/1964) was first to define them as a distinct type of memories. […]

In this article we review the results of recent research programmes offering insights into IAMs in psychopathology, ageing, and their relevance to the real world, and other subjective experiences, such as déjà vu. […]

Involuntary memories come in different forms. Some occur in pathological and drug-induced states, such as ‘flashbacks’ experienced by LSD users sometime after the original trip, triggered by auditory and visual cues. These flashbacks have been defined as ‘transient, spontaneous reoccurrences of the psychedelic drug effect.’ Generally, they decrease in intensity and frequency once drug taking ceases, but are often distressing and debilitating when they occur. Some of the defining features of memories in post-traumatic stress disorder (PTSD) are that they repeatedly intrude upon consciousness, are extremely distressing and are difficult to control. Spontaneous recurrence of past memories has also been noted in patients with temporal lobe epilepsy shortly before or during simple partial seizures.

However, more contemporary strands of research suggest that IAMs are actually a relatively normal part of our mental lives, and that they form a useful and important directive function, guiding present and future thinking and behaviour. Cues in the environment can provide rapid access to past experiences, which may have survival value in situations that could be life threatening, or require problems to be solved quickly.

IAMs occur spontaneously without any deliberate intention to recall anything. In fact they are most likely to occur when individuals are engaged in regular, automatic activities that are not attentionally demanding, such as walking, driving or eating. It is estimated that they occur on average three to five times a day, and up to three times as frequently as voluntary memories. So for most people they are common, unexceptional occurrences, but occasionally they can be extremely meaningful, as described by Proust, or surprising.

{ The Psychologist | Continue reading }

photo { Tereza Zelenkova, Cometes, 2012 }

The concept “superiority illusion” refers to the fact that people tend to judge themselves as being superior to the average person when it comes to positive traits such as intelligence, desirability or other personality traits. This is mathematically not possible, because in a normally distributed population, most people cannot be above average. The “superiority illusion” belongs to a family of positive illusions, such as the “optimism bias,” which is characterized by an unrealistic positive outlook regarding our future. It is thought that such positive illusions may help ward off depressive symptoms and promote mental health. […]

[A recent study suggests] that the degree of superiority illusion correlates negatively with functional connectivity between two parts of the brain (the anterior cingulate cortex and the striatum) and that the proposed mediator is the neurotransmitter dopamine. This would mean that increasing dopamine levels in the striatum could promote a person’s superiority illusion.

One limitation of the study was that the findings were purely associative and did not prove an actual causal link between dopamine levels and the superiority illusion.

{ Fragments of Truth | Continue reading }

The researchers also found that men require a slightly longer wavelength to see the same hue as women; an object that women experience as orange will look slightly more yellowish to men, while green will look more blue-green to men.

This last part doesn’t confer an advantage on either sex, but it does demonstrate, Abramov says, that “the nervous system that deals with color cannot be wired in the exact same way in males as in females.” He believes the answer lies in testosterone and other androgens.

{ Smithsonian | Continue reading }

photo { Nicholas Nixon }

The study suggests that we have limited ability to perceive mixed color-shape associations among objects that exist in several locations. […]

Say, for example, a person sees a string of letters, “XOOX,” and the letters are printed in alternating colors, red and green. Both letter shape and letter color need to be encoded, but the associations between letter shape and letter color are mixed (i.e., the first X is red, while the second X is green), which should make neural synchrony impossible.

“The perceptual system can either know how many Xs there are or how many reds there are, but it cannot know both at the same time,” Goldfarb and Treisman explain.

{ APS | Continue reading }

graphite, paint, and ink on paper { Abu Bakarr Mansaray }

Memory is a strange thing. Just using the verb “smash” in a question about a car crash instead of “bump” or “hit” causes witnesses to remember higher speeds and more serious damage. Known as the misinformation effect, it is a serious problem for police trying to gather accurate accounts of a potential crime. There’s a way around it, however: get a robot to ask the questions. […]

Two groups - one with a human and one a robot interviewer - were asked identical questions that introduced false information about the crime, mentioning objects that were not in the scene, then asking about them later. When posed by humans, the questions caused the witnesses’ recall accuracy to drop by 40 per cent - compared with those that did not receive misinformation - as they remembered objects that were never there. But misinformation presented by the NAO robot didn’t have an effect.

{ NewScientist | Continue reading }