The scientific study of heartbreak is extremely new, with nearly all articles on the matter appearing in the last 10-15 years. In fact, the notion that strong emotional stress can impact health was not widely accepted in academia until recently.
In the 1990’s, Japan started accruing cases of a disease called “takotsubo cardiomyopathy,” where patients’ hearts would actually become damaged and their ventricles would be misshapen (into that of a “takotsubo,” or octopus-catching pot – a very bad shape for a heart chamber). Curiously, these cases were not heart attacks, but instead were a form of heart failure brought on by a rush of stress hormones.
After 15 years, the syndrome was finally mentioned in a 2005 New England Journal of Medicine article, where it was renamed “Broken Heart Syndrome.” Among the causes of Broken Heart Syndrome are romantic rejection, divorce, or the death of a loved one, and the outcome can be as serious as death.