Every cell in our bodies runs on a 24-hour clock, tuned to the night-day, light-dark cycles that have ruled us since the dawn of humanity. The brain acts as timekeeper, keeping the cellular clock in sync with the outside world so that it can govern our appetites, sleep, moods, and much more.

But new research shows that the clock may be broken in the brains of people with depression—even at the level of the gene activity inside their brain cells.

It’s the first direct evidence of altered circadian rhythms in the brain of people with depression, and shows that they operate out of sync with the usual ingrained daily cycle. […]

In severely depressed patients, the circadian clock was so disrupted that a patient’s “day” pattern of gene activity could look like a “night” pattern—and vice versa.

{ Futurity | Continue reading | Thanks Tim }

Max Planck’s conception of progress in science:

A new scientific truth does not triumph by convincing its opponents and making them see the light, but rather because its opponents eventually die, and a new generation grows up that is familiar with it.

{ Theory, Evolution and Games Group | Continue reading }

There is plenty of evidence to suggest that brains can produce rather complex behavior without consciousness. Studies in humans show that we perform so much of our complex behavior unconsciously – from driving a car to investing our savings. There’s every reason to believe that most – if not all – non-human animal behavior we see could be being produced by an otherwise intelligent mind that is not producing subjective experiences of its own decision making processes. […]

Just because an animal behaves like a human, does this mean we should assume its mind functions in the same way? […] Banana-reaching via unconscious thought for the chimpanzee […] a computer might also be able to solve this problem, but we don’t suggest that computers are conscious. One of the main problems we’re dealing with here is that science does not really have a good definition of consciousness. Yes, it’s some form of subjective experience, but it might come in a variety of forms, and thus animals might be conscious in different ways to humans. […]

Scientists have given dolphins the mirror self recognition (MSR) test. Having some kind of awareness of oneself – whether it’s awareness of one’s body or of one’s own mind – is certainly linked to the idea of consciousness. For these tests, dolphins were marked with a kind of dye on their bodies, and if they then swam over to inspect the mark in a mirror, we could conclude that the dolphins must know that it’s themselves they are seeing in the mirror. This then is some kind of self awareness. […]

The problem is that being able to recognize one’s body in the mirror (that is, recognizing an external representation of one’s body) might not be the same thing as having a representation of one’s own mind (i.e., a sense of self). So passing the MSR test might not even be a sure test of self-awareness, let alone subjective experience.

{ Justin Gregg | Continue reading }

There is no scientific evidence that psychiatric diagnoses such as schizophrenia and bipolar disorder are valid or useful, according to the leading body representing Britain’s clinical psychologists.

In a groundbreaking move that has already prompted a fierce backlash from psychiatrists, the British Psychological Society’s division of clinical psychology (DCP) will on Monday issue a statement declaring that, given the lack of evidence, it is time for a “paradigm shift” in how the issues of mental health are understood. The statement effectively casts doubt on psychiatry’s predominantly biomedical model of mental distress – the idea that people are suffering from illnesses that are treatable by doctors using drugs.

Dr Lucy Johnstone, a consultant clinical psychologist who helped draw up the DCP’s statement, said it was unhelpful to see mental health issues as illnesses with biological causes.

“On the contrary, there is now overwhelming evidence that people break down as a result of a complex mix of social and psychological circumstances – bereavement and loss, poverty and discrimination, trauma and abuse,” Johnstone said. The provocative statement by the DCP has been timed to come out shortly before the release of DSM-5, the fifth edition of the American Psychiatry Association’s Diagnostic and Statistical Manual of Mental Disorders.

The manual has been attacked for expanding the range of mental health issues that are classified as disorders.

{ The Observer | Continue reading }

images { Kazuki Takamatsu | Maja Daniels }

On August 31, 2012, Japanese mathematician Shinichi Mochizuki posted four papers on the Internet.

The titles were inscrutable. The volume was daunting: 512 pages in total. The claim was audacious: he said he had proved the ABC Conjecture, a famed, beguilingly simple number theory problem that had stumped mathematicians for decades. […]

The problem, as many mathematicians were discovering when they flocked to Mochizuki’s website, was that the proof was impossible to read. The first paper, entitled “Inter-universal Teichmuller Theory I: Construction of Hodge Theaters,” starts out by stating that the goal is “to establish an arithmetic version of Teichmuller theory for number fields equipped with an elliptic curve…by applying the theory of semi-graphs of anabelioids, Frobenioids, the etale theta function, and log-shells.”

This is not just gibberish to the average layman. It was gibberish to the math community as well.

{ Caroline Chen/Project Wordsworth | Continue reading }

art { Cy Twombly, Coronation of Sesostris, 2000 }

Most people do not seem to perceive microexpressions in themselves or others. In the Wizards Project, previously called the “Diogenes Project,” Drs. Paul Ekman and Maureen O’Sullivan studied the ability of people to detect deception. Of the thousands of people tested, only a select few were able to accurately detect when someone was lying. The Wizards Project researchers named these people “Truth Wizards.” To date, the Wizards Project has identified just over 50 people with this ability after testing nearly 20,000 people. Truth Wizards use microexpressions, among many other cues, to determine if someone is being truthful. Scientists hope by studying wizards that they can further advance the techniques used to identify deception.

{ Wikipedia | Continue reading }

art { Eli Craven }

“What people do in cities—create wealth, or murder each other—shows a relationship to the size of the city, one that isn’t tied just to one era or nation,” says Lobo. The relationship is captured by an equation in which a given parameter—employment, say—varies exponentially with population. In some cases, the exponent is 1, meaning whatever is being measured increases linearly, at the same rate as population. Household water or electrical use, for example, shows this pattern; as a city grows bigger its residents don’t use their appliances more. […]

If the population of a city doubles over time, or comparing one big city with two cities each half the size, gross domestic product more than doubles. Each individual becomes, on average, 15 percent more productive. Bettencourt describes the effect as “slightly magical,” although he and his colleagues are beginning to understand the synergies that make it possible. Physical proximity promotes collaboration and innovation, which is one reason the new CEO of Yahoo recently reversed the company’s policy of letting almost anyone work from home. […]

Remarkably, this phenomenon applies to cities all over the world, of different sizes, regardless of their particular history, culture or geography. Mumbai is different from Shanghai is different from Houston, obviously, but in relation to their own pasts, and to other cities in India, China or the U.S., they follow these laws.

{ Smithsonian | Continue reading }

art { Alex Roulette }

The microbiome — the kilogram of microbes that each of us carries around — has been shown to be involved in everything from obesity and type 2 diabetes to behaviour and sexual preferences. The composition and effects of the microbiome are very active areas of research, producing results which have challenged the way we think about the evolution and interactions of organisms, including ourselves. In a paper recently published in the journal Science, researchers showed for the first time that the make up of the microbiome differs between the sexes, linking these differences to changes in hormone levels and disease resistance. […]

When female mice were given a testosterone inhibitor along with the bacteria from male mice, the rate of diabetes returned to normal.

“It was completely unexpected to find that the sex of an animal determines aspects of their gut microbe composition, that these microbes affect sex hormone levels, and that the hormones in turn regulate an immune-mediated disease,” said Dr. Danska.

{ Inspiring Science | Continue reading }

photo { Jackie Hardt }

Normal vision is essentially a spatial sense that often relies upon touch and movement during and after development, there is often a correlation between how an object looks and how it feels.

Moreover, as a child’s senses develop, there is cross-referencing between the various senses. Indeed, where the links between the senses are not made, there may be developmental problems or delays.

This should be taken into consideration when training new users of visual prosthetics, artificial retinas, or bionic eyes, suggest researchers in Australia.

{ EurekAlert | Continue reading }

photo { Elena Amagro }

Proponents of Neuro-Linguistic Programming (NLP) claim that certain eye-movements are reliable indicators of lying. According to this notion, a person looking up to their right suggests a lie whereas looking up to their left is indicative of truth telling. Despite widespread belief in this claim, no previous research has examined its validity. […]

Three studies provided no evidence to support the notion that the patterns of eye-movements promoted by many NLP practitioners aid lie detection. This is in line with findings from a considerable amount of previous work showing that facial clues (including eye movements) are poor indicators of deception.

{ PLoS | Continue reading }

In 1884, Scientific American asked and answered the famous question, “if a tree were to fall on an uninhabited island, would there be any sound?” […] “If there be no ears to hear, there will be no sound.” […]

Dolphins, for instance, hear 150–150,000 Hz oscillations, whereas humans hear in the range of 20–20,000 Hz. We perceive only as much of reality as our mechanisms of transduction, our sensory organs, afford us. The remainder, the un-transduced portion, is lost to oblivion (or to instrumentation). Transduction induces both veridical representation and editorializing on the biological value of events and objects, such as fright at the apprehension of threat. Morality, perhaps counterintuitively, begins with editorialized sensation. […]

Churchland describes her project as examining the platform upon which morality is constructed. Her thesis is that the platform is maternal attachment to young. The largest single factor in human brain evolution is our exaggerated juvenile phase, during much of which we are helpless. This surely exerted strong selective pressure for parental behavior, care for kin. Churchland argues this is the forerunner of care for kith and strangers. Haidt, drawing from cross-cultural psychology, argues that the normative bedrock is not monolithic. He proposes six innate dimensions about which we are predisposed toward moralizing: harm-care, fairness-cheating, liberty-oppression, loyalty-betrayal, authority-subversion and sanctity-degradation.

{ The American Interest | Continue reading }

Despite an understanding of the perception and consequences of apologies for their recipients, little is known about the consequences of interpersonal apologies, or their denial, for the offending actor.

In two empirical studies, we examined the unexplored psychological consequences that follow from a harm-doer’s explicit refusal to apologize.

Results showed that the act of refusing to apologize resulted in greater self-esteem than not refusing to apologize. Moreover, apology refusal also resulted in increased feelings of power/control and value integrity, both of which mediated the effect of refusal on self-esteem.

{ European Journal of Social Psychology/Wiley | Continue reading }