*sighs heavily, walks over to big DAYS SINCE MAX GOT TOO DRUNK AT AN OFFICE PARTY AND EMBARRASSED HIMSELF sign, flips number back to 0* —Max Read

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15 years ago, the neurosciences defined the main function of brains in terms of processing input to compute output: “brain function is ultimately best understood in terms of input/output transformations and how they are produced” wrote Mike Mauk in 2000.

Since then, a lot of things have been discovered that make this stimulus-response concept untenable and potentially based largely on laboratory artifacts.

For instance, it was discovered that the likely ancestral state of behavioral organization is one of probing the environment with ongoing, variable actions first and evaluating sensory feedback later (i.e., the inverse of stimulus response). […]

In humans, functional magnetic resonance imaging (fMRI) studies over the last decade and a half revealed that the human brain is far from passively waiting for stimuli, but rather constantly produces ongoing, variable activity, and just shifts this activity over to other networks when we move from rest to task or switch between tasks.

{ Björn Brembs | Continue reading }

And God shall wipe away every tear from their eyes, and the death shall not be any more

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Furans are coffee’s dirty little secret. Although we can thank them for the pleasant aroma and delicious flavour of freshly brewed coffee, furans have been labelled as a possible human carcinogen (cause of cancer) in disguise by food safety agencies including the United States Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA).

Furans enter our food chain through canned, bottled and jarred processed foods, but 85% of furan exposure in adults is from coffee consumption. All these products undergo ultra-high temperature (UHT) treatment and furans are one of the carcinogenic compounds produced. The canned, bottled and jarred foods are sterilized this way to eradicate disease-causing micro-organisms and to increase their shelf-life. Coffee beans are heated to even higher temperatures during roasting. Furans are volatile and not very water-soluble so how you like your coffee, roasted, ground, stored and brewed, will determine how much furan is left in your cup of Joe. […]

Arisseto and colleagues (2011) […] found that furan content was higher in Robusta samples. […]

Altaki and colleagues (2011) found regular decaffeinated or caffeinated brews made with an espresso machine had higher furan content than a drip coffee maker, and instant coffee brews had relatively low levels whilst coffee capsules contained the most. […]

Leaving your cup of coffee to stand at room temperature for 30 minutes before drinking will reduce furan amounts by 25% according to Guenther and colleagues (2010).

{ United Academics | Continue reading }

Every day, the same, again

44.jpgBuying human breast milk online poses serious health risk, say experts

Researchers may have solved origin-of-life conundrum

A power nap of under an hour can improve memory performance by five times, a new study finds.

One thousand genes you could live without

Can We Interpret Smoking Habits in Historic Skeletal Remains?

Anthropologists have shown that the practice of cannibalism is very often linked to magic, as the provider of the most potent ingredients to make ‘medicine’ to make a person bullet-proof, able to fly, all-powerful, and many more wondrous things.

Scientists have discovered a simple way to cook rice that reduces its calories by as much as 50 percent

Algorithm Clones Facial Expressions… And Pastes Them Onto Other Faces

There are only four people/organizations in the world who know my location at all times: my wife (because I tell her), Apple (because Siri), the NSA (because NSA), and now Uber.

Manipulating Wikipedia to Promote a Bogus Business School

Tinder hack made hundreds of bros unwittingly flirt with each other

Kinetic sculpture by Jennifer Townley

Four circles, and none of them touch

She said, Damn fly guy I’m in love with you

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{ Margret: Chronicle of an Affair – May 1969 to December 1970 | found materials relating to a private affair conducted between a German businessman and his secretary in the late 1960s and early 1970s. }

Every day, the same, again

4523.jpgUS researchers are investigating ways to extract the gold and precious metals from human faeces.

Radioactive sanitary pads from China seized by authorities in Lebanon [Thanks Tim]

New Alzheimer’s treatment fully restores memory function

Excess Time Indoors May Explain Rising Myopia Rates

A relationship between temperature and aggression in NFL football penalties

MIT discovers a new state of matter, a new kind of magnetism

Can Space Expand Faster Than the Speed of Light?

Bestselling books, 1900-1999

Sneeze catcher (new patent)

Management wants you gone by the end of the day

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Anthropodermic bibliopegy is the practice of binding books in human skin. Though extremely uncommon in modern times, the technique dates back to at least the 17th century. The practice is inextricably connected with the practice of tanning human skin, often done in certain circumstances after a corpse has been dissected.

Surviving historical examples of this technique include anatomy texts bound with the skin of dissected cadavers, volumes created as a bequest and bound with the skin of the testator, and copies of judicial proceedings bound in the skin of the murderer convicted in those proceedings, such as in the case of John Horwood in 1821 and the Red Barn Murder in 1828.

{ Wikipedia | Continue reading }

Every day, the same, again

211.jpgSufficient sleep is important for healthy sexual desire

A psychology study sheds new light on today’s standards of beauty, attributing modern men’s preferences for women with a curvy backside to prehistoric influences.

Religiosity and participation in religious activities have been linked with decreased risky behavior

Psychopathic tendencies in chimpanzees

The Science of Near-Death Experiences

Can Synesthesia Be Learned?

Can you really catch a disease from bad bathroom smells?

How solar eclipses cause problems for countries that rely on solar power

The oddly beautiful (and sometimes disturbing) uniform patches of the DEA

‘If you write something and put a date after it, it suddenly becomes an art project, 2015’ —Evander Batson

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Doctor Tsun arrives at the house of Doctor Albert, who is deeply excited to have met a descendant of Ts’ui Pên. Doctor Albert reveals that he has himself been engaged in a longtime study of Ts’ui Pên’s novel. Albert explains excitedly that at one stroke he has solved both mysteries—the chaotic and jumbled nature of Ts’ui Pên’s unfinished book and the mystery of his lost labyrinth. Albert’s solution is that they are one and the same: the book is the labyrinth.

{ Plot summary of The Garden of Forking Paths/Wikipedia | Continue reading }

The whool of the whaal in the wheel of the whorl

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A group of leading biologists called for a worldwide moratorium on use of a new genome-editing technique that would alter human DNA in a way that can be inherited.

The biologists fear that the new technique is so effective and easy to use that some physicians may push ahead before its safety can be assessed. They also want the public to understand the ethical issues surrounding the technique, [which holds the power to repair or enhance any human gene, and] could be used to cure genetic diseases, but also to enhance qualities like beauty or intelligence.

{ NY Times | Continue reading }

Genome-editing technologies may offer a powerful approach to treat many human diseases, including HIV/AIDS, haemophilia, sickle-cell anaemia and several forms of cancer. All techniques currently in various stages of clinical development focus on modifying the genetic material of somatic cells, such as T cells (a type of white blood cell). These are not designed to affect sperm or eggs. […]

The newest addition to the genome-editing arsenal is CRISPR/Cas9, a bacteria-derived system that uses RNA molecules that recognize specific human DNA sequences. The RNAs act as guides, matching the nuclease to corresponding locations in the human genome.

{ Nature | Continue reading }

photo { Darren Holmes }

related { Genetic Origins of Economic Development }

‘The best weapon against an enemy is another enemy.’ —Nietzsche

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The Holodomor (Ukrainian: Голодомор, “Extermination by hunger”) was a man-made famine in the Ukrainian Soviet Socialist Republic in 1932 and 1933 that killed an estimated 2.5-7.5 million Ukrainians, with millions more counted in demographic estimates. It was part of the wider disaster, the Soviet famine of 1932–33, which affected the major grain-producing areas of the country.

During the Holodomor, which is also known as the “Terror-Famine in Ukraine” and “Famine-Genocide in Ukraine,” millions of citizens of the Ukrainian SSR, the majority of whom were ethnic Ukrainians, died of starvation in a peacetime catastrophe unprecedented in the history of Ukraine. Since 2006, the Holodomor has been recognized by the independent Ukraine and many other countries as a genocide of the Ukrainian people carried out by the Soviet Union.

Scholars disagree on the relative importance of natural factors and bad economic policies as causes of the famine but believe it was a long term plan of Joseph Stalin, an attempt to eliminate the Ukrainian independence movement.

{ Wikipedia | Continue reading }

Territorial expansion of the 1933 famine is a matter of dispute between Ukrainian and Russian history scientists. The former regard the famine to be localized within Ukraine, while the latter adopt the position that vast regions of Russia, in particular the Volga River region and Central Chernozemic region, were affected with the famine too. To solve this matter, the author has the data engaged which concern nutrition survey conducted by Gosplan (State Planning Committee) of the USSR in 1933. These data show that the situation in Ukraine was the most disastrous. The Volga River and Central Chernozemic regions, although suffered from the famine too, were featured with consumption of food products about 1.5 times higher than that in Odessa or Kiev regions. The average daily consumption of 1070 kcal which was recorded in Odessa region in early 1933 allowed life- sustaining activity of a human being for three months only

{ Economics & Sociology | PDF }

And now we’re flyin’ through the stars, I hope this night will last forever

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{ American scientist James Stuckey and volunteer Judy Creeden demonstrate the human body’s ability to function as a conductor of electricity during a lecture in New York sponsored by the Atomic Energy Commission, 1966 | photo by F. Roy Kemp }

What one refuses in a minute, no eternity will return

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8,000 Years Ago, 17 Women Reproduced for Every One Man

[A] member of the research team, a biological anthropologist, hypothesizes that somehow, only a few men accumulated lots of wealth and power, leaving nothing for others. These men could then pass their wealth on to their sons, perpetuating this pattern of elitist reproductive success. Then, as more thousands of years passed, the numbers of men reproducing, compared to women, rose again. “Maybe more and more people started being successful,” Wilson Sayres says. In more recent history, as a global average, about four or five women reproduced for every one man.

{ Pacific Standard | Continue reading }

The boots to them, them in the bar

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Our eyes are drawn to several dimensions of an object–such as color, texture, and luminance–even when we need to focus on only one of them, researchers at New York University and the University of Pennsylvania have found. The study, which appears in the journal Current Biology, points to the ability of our visual system to integrate multiple components of an item while underscoring the difficulty we have in focusing on a particular aspect of it.

{ EurekAlert | Continue reading }

photo { George Pitts }

When love absorbs. War! War! The tympanum.

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The ability to express empathy — the capacity to share and feel another’s emotions — is limited by the stress of being around strangers, according to a new study.

{ ScienceDaily | Continue reading }

related { People in the study were more likely to disclose something personal about themselves after laughing together, although they didn’t realize it. }

Every day, the same, again

Too Many Scientific Studies, Study Finds

Using a Foreskin to Repair Eyelids

Scientists discover how to change human leukemia cells into harmless immune cells

Homeopathy not effective for treating any condition

A few people become inebriated simply by eating carbohydrates

The origin of the anus

The effects of being in a “new relationship” on levels of testosterone in men [PDF]

5 Languages That Could Change the Way You See the World

Plastics designed to degrade don’t break down any faster than their conventional counterparts, according to research

Passports for a Price: The Business Showing Poor Countries How to Sell Citizenship

Construction of airports is proceeding at a blistering pace in China

Hertz puts cameras in its rental cars, says it has no plans to use them

In 2009, a man calling himself Peter Bergmann arrived in an Irish town with a plan to disappear forever

How To Break Free If Your Hands Are Bound With Duct Tape

Tinder Users at SXSW Are Falling for This Woman, but She’s Not What She Appears

Things Bodies Can Do After Death [Thanks Nathan]

DNA-based prediction of Nietzsche’s voice

Oculus Rex

Miss Kennedy with manners transposed the teatray down to an upturned lithia crate, safe from eyes, low.

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‘Brand ambassador grabbed my ass! Then found a QR code coupon for a butt firming cream there. Pulled muscle trying to scan it #sxsw’ —Tim Geoghegan

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‘Humility is pain arising from a person’s contemplation of their own impotence.’ —Spinoza

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Over a decade ago, psychologist Barry Schwartz published what might be the ultimate psychological life-hacking tome, The Paradox of Choice: Why More Is Less. […]

If you ever aren’t sure if you attended the very best party or bought the very best computer, just settle for “good enough.” People who do this are called “satisficers,” and they’re consistently happier, he’s found, than are “maximizers,” people who feel that they must choose the very best possible option. Maximizers earn more, Schwartz has found, but they’re also less satisfied with their jobs. In fact, they’re more likely to be clinically depressed in general.

The reason this happens, as Schwartz explained in a paper with his Swarthmore colleague Andrew Ward, is that as life circumstances improve, expectations rise. People begin comparing their experiences to peers who are doing better, or to past experiences they’ve personally had that were better. […]

Schwartz’ solution […] just settle for something that’s acceptable—even if you know there’s likely something better out there.

{ The Atlantic | Continue reading }

photo { Jeff Mermelstein, New York City, c. 1993-1997 }

The letter R is also just a loop with two legs. Hence, the letters A and R are homeomorphic.

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Snapchat, the photo-messaging app raising cash at a $15 billion valuation, probably isn’t actually worth more than Clorox or Campbell Soup. So where did investors come up with that enormous headline number?

Here’s the secret to how Silicon Valley calculates the value of its hottest companies: The numbers are sort of made-up. For the most mature startups, investors agree to grant higher valuations, which help the companies with recruitment and building credibility, in exchange for guarantees that they’ll get their money back first if the company goes public or sells. They can also negotiate to receive additional free shares if a subsequent round’s valuation is less favorable. Interviews with more than a dozen founders, venture capitalists, and the attorneys who draw up investment contracts reveal the most common financial provisions used in private-market technology deals today. […]

Billion-dollar companies join a club of “unicorns,” a term used to explain how rare they are. But there are more than 50 of them now. There’s a new buzzword, “decacorn,” for those over $10 billion, which includes Airbnb, Dropbox, Pinterest, Snapchat, and Uber. It’s a made-up word based on a creature that doesn’t exist.

{ Bloomberg | Continue reading }

On the impossibility of drawing a map of the empire on a scale of 1 to 1

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