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Why is aspirin toxic to cats?

One animal’s cure can be another animal’s poison. Take aspirin – it’s one of the most popular drugs on the market and we readily use it as a painkiller. But cats are extremely sensitive to aspirin, and even a single extra-strength pill can trigger a fatal overdose. Vets will sometimes prescribe aspirin to cats but only under very controlled doses.

The problem is that cats can’t break down the drug effectively. They take a long time to clear it from their bodies, so it’s easy for them to build up harmful concentrations. This defect is unusual – humans clearly don’t suffer from it, and neither do dogs. All cats, however, seem to share the same problem, from house tabbies to African lions.

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The term big cat – which is not a biological classification – is used informally to distinguish the larger felid species from smaller ones. One definition of “big cat” includes the four members of the genus Panthera: the tiger, lion, jaguar, and leopard. Members of this genus are the only cats able to roar. A more expansive definition of “big cat” also includes the cheetah, snow leopard, clouded leopard, and cougar.

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