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For all those brunettes wishing they were naturally blond, a small genetic change could have made all the difference. Scientists have found that replacing one of DNA’s four letters at a key spot in the genome shifts a particular gene’s activity and leads to fairer hair. Not only does the work provide a molecular basis for flaxen locks, but it also demonstrates how changes in segments of DNA that control genes, not just changes in genes themselves, are important to what an organism looks like. […]

Over the past 6 years, studies of genetic variation in thousands of people have linked at least eight DNA regions to blondness based on the fact that a certain DNA letter, or base, was found in people with that hair color but not in people with other hair colors. Some of those base changes, or single-nucleotide polymorphisms (SNPs), were in genes involved in the production of pigments, such as melanin. Mutations in these genes typically change skin and hair color. Other SNPs lay outside genes but could be part of the regulatory DNA that helps control the function of genes nearby. Changes in that regulatory DNA could result in hair color but not skin color change, or vice versa, because regulatory DNA can change gene activity in just certain parts of the body.

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